Ah, a classic language question! The opposite gender of brother is sister.
Think of it like this: brothers and sisters are part of a family unit. They may have similar traits or interests, but they have different biological roles in relation to one another. When you're referring to a male sibling, you would use "brother." However, when referring to a female sibling, you would use "sister." It's important to remember that language holds a lot of power in how we communicate with one another. So next time someone asks you about the opposite gender of a brother, you'll know just how to answer!
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